- DNAF can often be associated with normal semen analysis
- DNAF can be improved with antioxidant vitamin regimen in some cases
- DNAF can often be associated with varicocele and most often it is improved after varicocele surgery
- DNAF can be associated with exposure to toxic chemicals, smoking and excessive alcohol intake
- DNAF can be improved with hormone treatment in some cases.
- DNAF is often present in couples with 'unexplained infertility', thus actually explaining the problem
- The worse the semen parameters on the traditional semen analysis, the more likely DNA fragmentation is present also.
- DNAF can be measured in specific labs only, but all evaluations of the semen can be done through our office on a single sample in the majority of cases.
- DNAF of the sperm can affect the outcome of IVF procedures such as poor fertilization, poor embyro development, and early pregnancy loss/negative pregnancy test.
- DNAF Is associated with lower chances of success with IUI cycles also.
- When there are problems with the traditional semen analysis and DNA fragmentation, the best treatment is most likely IVF and ICSI to optimize success.
- DNAF can be affected by increasing male age.
- DNAF is associated with exposure to 'heavy metals' like lead, mercury, cadmium, etc.
We are learning constantly about the problem and how DNAF affects fertility. However, there are some obvious things that we can do to improve the fertility potential and increase the success of treatments like IUI and IVF. The first important thing to do is to evaluate whether DNAF is present with the simple tests recommended. Then we can deal with it as best as possible to enhance the chances of success.
Please contact me if we can discuss or provide further information.Peter Ahlering MD
SIRM St Louis
pahlering@sherinstitute.com
314-983-9000
http://www.haveababy.com/
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